About this site
Islets of Langerhans, often called just islets are small organs present in the pancreas. They contain different types of cells that secrete hormones like insulin, glucagon, and somatostatin. Impairment of islet function cause diabetes. Numerous scientists are doing research on islets and I am one of them. This website is about my academic background and my involvement in islet research.
My CV
Education
PhD in Cell Biology - Diabetes, Department of Molecular Medicine, Faculty of Medicine, Karolinska Institutet, Stockholm, Sweden — Awarded May 19, 1995
Awarded the title of Associate Professor (Swedish Docent) in Experimental Endocrinology at Karolinska Institutet, January 13, 1999
Specialist in Internal Medicine, certified by the Swedish National Board of Health and Welfare — March 3, 2007
Licensed Physician, certified by the Swedish National Board of Health and Welfare — February 23, 2005
Certified by the Educational Commission for Foreign Medical Graduates (ECFMG), USA — January 27, 1987
Bachelor of Medicine, Bachelor of Surgery, (with six honors), Chittagong Medical College, Bangladesh — October 14, 1980
My Publications
Islam, M. S. 2025. Ryanodine Receptors in Islet Cell Function: Calcium Signaling, Hormone Secretion, and Diabetes. Cells 14(10):690.doi: 10.3390/cells14100690.
Matos, GM, Andersson, B, Islam, MS. 2022. Expression of Transient Receptor Potential Channel Genes and Their Isoforms in Alpha-Cells and Beta-Cells of Human Islets of Langerhans. J Diabetes Re. 2022 Aug 3;2022:3975147. doi: 10.1155/2022/397145
Islam, M. S. 2021. Diabetes: From Research to Clinical Practice. Adv Exp Med Biol. 1307:1-5. doi: 10.1007/5584_2020_553
Nordenskjold, F., Andersson, B., Islam, M. S. 2020. Expression of the Inositol 1,4,5-Trisphosphate Receptor and the Ryanodine Receptor Ca(2+)-Release Channels in the Beta-Cells and Alpha-Cells of the Human Islets of Langerhans. Adv Exp Med Biol. 1131:
271-279. doi: 10.1007/978-3-030-12457-1_11.
Islam, M. S. 2020 Stimulus-Secretion Coupling in Beta-Cells: From Basic to Bedside. Adv Exp Med Biol. 1131:943-963. doi: 10.1007/978-3-030-12457-1_37.
Islam, M. S. 2020. Calcium Signaling: From Basic to Bedside. Adv Exp Med Biol. 1131:1-6. doi: 10.1007/978-3-030-12457-1_1.
Islam, M. S. 2020. Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells. Cells. 9:685-707. doi: 10.3390/cells9030685.
Islam, M. S. 2018. Heart Failure: From Research to Clinical Practice. Adv Exp Med Biol. 1067:1-3. doi: 10.1007/5584_2018_181.
Islam, M. S. 2018. The Art and Science of Using Diuretics in the Treatment of Heart Failure in Diverse Clinical Settings. Adv Exp Med Biol. 1067:47-65. doi: 10.1007/5584_2018_182.
Schulman, S., Islam, M. S. 2017. Recent Advances in Thrombosis and Hemostasis-Part II. Semin Thromb Hemost. 43:809-810. doi: 10.1055/s-0037-1605566.
Marabita, F., Islam, M. S. 2017. Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic beta-Cells. Pancreas. 46:97-101. doi: 10.1097/MPA.0000000000000685.
Ma, Z., Bjorklund, A., Islam, M. S. 2017. A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans. J Diabetes Res. 2017:5131785. doi: 10.1155/2017/5131785.
Islam, M. S. Schulman, S. 2017. Berzelius Symposium 93: International Conference on Thrombosis and Embolism. Semin Thromb Hemost. 43:811-813. doi: 10.1055/s-0037-1605565.
Islam, M. S. 2017. Thrombolytic Therapy by Tissue Plasminogen Activator for Pulmonary Embolism. Adv Exp Med Biol. 906:67-74. doi: 10.1007/5584_2016_106.
Islam, M. S., 2017. Ambulatory Blood Pressure Monitoring in the Diagnosis and Treatment of Hypertension. Adv Exp Med Biol. 956:109-116. doi: 10.1007/5584_2016_177.
Islam, M. S. 2017. Hypertension: From Basic Research to Clinical Practice. Adv Exp Med Biol. 956:1-2. doi: 10.1007/5584_2017_30.
Schulman, S., Islam, M. S. 2016. Recent Advances in Thrombosis and Hemostasis - Part I. Semin Thromb Hemost. 42:805-807. doi: 10.1055/s-0036-1593544.
Prandoni, P., Bernardi, E., Valle, F. D., Visona, A., Tropeano, P. F., Bova, C., Bucherini, E.. Islam, M. S.. Piccioli, A. 2016. Extensive Computed Tomography versus Limited Screening for Detection of Occult Cancer in Unprovoked Venous Thromboembolism: A Multicenter, Controlled, Randomized Clinical Trial. Semin Thromb Hemost. 42:884-890.
doi: 10.1055/s-0036-1592335.
Krishnan, K., Ma, Z., Bjorklund, A., Islam, M. S. 2015. Calcium signaling in a genetically engineered human pancreatic beta-cell line.
Pancreas. 44:737-777. doi: 10.1097/MPA.0000000000000318.
Islam, M. S. 2015. Calcium Signaling in the Islets.In: Islam, M. S., editor. The Islets of Langerhans. 2nd ed. Dodrecht: Springer; p. 605-632. doi:10.1007/978-94-007-6884-0_9-2.
Rebellato, P., Islam, M. S. 2014. [6]-shogaol induces Ca2+ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells. JOP. 15:33-37. doi: 10.6092/1590-8577/1979.
Rebellato, P. Islam, M. S. 2014. Reply to Comments on the article "[6]-Shogaol induced calcium signal in rat insulinoma cells". JOP. 15:212. doi: 10.6092/1590-8577/2288.
Krishnan, K., Ma, Z., Bjorklund, A., Islam, M. S. 2014. Role of transient receptor potential melastatin-like subtype 5 channel in insulin secretion from rat beta-cells. Pancreas. 43:697-604. doi: 10.1097/MPA.0000000000000027.
Fagelskiold, A. J., Kannisto, K., Bostrom, A., Hadrovic, B., Farre, C., Eweida, M., Wester, K., Islam, M. S. 2012. Insulin-secreting INS-1E cells express functional TRPV1 channels. Islets. 4:56-63. doi: 10.4161/isl.18915.
Islam, M. S. 2011. TRP channels of islets. Adv Exp Med Biol. 704:811-30. doi: 10.1007/978-94-007-0265-3_42.
Gustafsson, A. J., Muraro, L., Dahlberg, C., Migaud, M., Chevallier, O., Khanh, H. N., Krishnan, K., Li, N., Islam, M. S. 2011.
ADP ribose is an endogenous ligand for the purinergic P2Y1 receptor. Mol Cell Endocrinol. 333:8-19.
doi: 10.1016/j.mce.2010.11.004.
Islam, M. S. 2010. Calcium signaling in the islets. Adv Exp Med Biol. 654:235-59. doi: 10.1007/978-90-481-3271-3_11.
Islam, M. S. 2010. An estimated 285 million people in the world have islet failure. Islets. 2:209. doi: 10.4161/isl.2.4.13326.
Islam, M. S. 2010. CICR takes centre stage in beta-cells: a cute cascade connects cAMP to CICR. J Physiol. 588:4853. doi:10.1113/jphysiol.2010.202291
Goswami, C., Islam, M. S. 2010. Transient Receptor Potential channels: What's happening? Reflections in the wake of the 2009 TRP Meeting, Karolinska Institutet, Stockholm. Channels (Austin). 4:124-35. 10.4161/chan.4.2.11478
Bari, M. R., Akbar, S., Eweida, M., Kuhn, F. J., Gustafsson, A. J., Luckhoff, A., Islam, M. S. 2009. H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med. 13:
3260-7. 10.1111/j.1582-4934.2009.00737.x
Islam, M. S., Gustafsson, A. J. 2007. Islets of Langerhans: Cellular structure and physiology. In: Ahsan N, editor. Chronic allograft failure: natural history, pathogenesis, diagnosis and management. Austin (TX): Landes Bioscience; 2010. p. 229–232. DOI: 10.1201/9781498712729-37
Woolcott, O.O., Gustafsson, A.J., Dzabic, M., Pierro, C., Tedeschi, P., Sandgren, J., Bari, M.R., Nguyen, K.H., Bianchi, M., Rakonjac, M., Radmark, O., Ostenson, C.G., and Islam, M.S. 2006. Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic beta-cells. Cell Calcium. 39:529-37. doi: 10.1016/j.ceca.2006.02.003.
Gustafsson, A. J. Ingelman-Sundberg, H. Dzabic, M. Awasum, J. Nguyen, K. H. Ostenson, C. G. Pierro, C. Tedeschi, P. Woolcott, O. Chiounan, S. Lund, P. E. Larsson, O. Islam, M. S. 2005. Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells. FASEB J. 19:301-3. DOI:10.1096/fj.04-2621fje
Gustafsson, A. J., Islam, M. S. 2005. Cellulär kalciumjonssignalering – från grundforskning till patientnytta. [Cellular calcium ion signalling--from basic research to benefits for patients]. Läkartidningen. 102:3214-9. PMID: 163294
Islam, M. S. Rahman, S. A. Mirzaei, Z. Islam, K. B. 2005. Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness. Life Sci. 76: 1239-48. DOI:10.1016/j.lfs.2004.08.021
Quynh, N. T. Islam, M. S. Floren, A. Bartfai, T. Langel, U. Ostenson, C. G. 2005. Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem Biophys Res Commun. 328: 213-20 DOI:10.1016/j.bbrc.2004.12.150
Stay tuned for the latest updates on my professional journey.
Exciting new publications added to my growing body of work.
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